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产品描述:
Crisaborole是选择性的小分子PDE4抑制剂,具有广谱的抗炎活性。
靶点:
PDE4
(Cell-free assay)
体内研究:
Crisaborole is well tolerated and not tumorigenic in mice.
中文别名:
克瑞沙硼; 克立硼罗; 4-((1-羟基-1,3-二氢苯并[C][1,2]氧杂硼戊环-5-基)氧)苯甲腈
物化属性:
PSA:62.48000
LOGP:1.56828
[1]. Akama T, et al. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32.
[2]. Nazarian R, et al. AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis. Curr Opin Investig Drugs. 2009 Nov;10(11):1236-42.
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