0576-88813233
GSK 650394 是一种新颖的 SGK 抑制剂,在SPA实验中,对 SGK1 和 SGK2 的IC50 分别为 62 nM 和 103 nM。
物化属性:
PSA:65.98000
LOGP:6.25270
[1]. Sherk AB, et al. Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res. 2008 Sep 15;68(18):7475-83.
[2]. Mansley MK, et al. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption. Br J Pharmacol. 2010 Oct;161(3):571-88.
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