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曲前列环素 Treprostinil (LRX-15) 是高效的DP1和EP2激动剂,其EC50值分别为0.6±0.1和6.2±1.2 nM。
物化性质
密度:1.158g/cm3
沸点:587.1ºC at 760mmHg
闪点:199.3ºC
折射率:1.553
[1]. Whittle BJ, et al. Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist. Biochem Pharmacol. 2012 Jul 1;84(1):68-75.
[2]. Ferrantino M, et al. Inhaled treprostinil sodium for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2011 Nov;12(16):2583-93.
[3]. Ghonem N, et al. Treprostinil, a prostacyclin analog, ameliorates ischemia-reperfusion injury in rat orthotopic liver transplantation. Am J Transplant. 2011 Nov;11(11):2508-16.
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