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Pyroxamide

Pyroxamide 382180-17-8
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产品信息
产品名称:Pyroxamide 纯度:98% min
CAS NO:382180-17-8 溶解度:
分子式:C13H19N3O3 包装:可按客户要求包装
分子量:265.308 贮存:-20℃
质量控制
备注说明

Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes implicated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.

 

中文别名:

N-羟基-N'-3-吡啶基辛烷二酰胺


物化属性:

密度:1.215

折射率:1.569

PSA:91.32000

LOGP:2.33000

 

参考文献

1: Einsiedel HG, Kawan L, Eckert C, Witt O, Fichtner I, Henze G, Seeger K. Histone deacetylase inhibitors have antitumor activity in two NOD/SCID mouse models of B-cell precursor childhood acute lymphoblastic leukemia. Leukemia. 2006 Aug;20(8):1435-6. Epub 2006 Jun 29. PubMed PMID: 16810202.

2: Kouraklis G, Theocharis S. Histone deacetylase inhibitors: a novel target of anticancer therapy (review). Oncol Rep. 2006 Feb;15(2):489-94. Review. PubMed PMID: 16391874.

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