你好!欢迎访问 登录|立即注册

0576-88813233

|
当前位置:科瑞产品

吡咯替尼二马来酸盐 Pyrotinib Maleate

吡咯替尼二马来酸盐 Pyrotinib Maleate 1397922-61-0
规格 价格 库存 数量
在线咨询 大包装询价 加入购物车
如您需要更多数量的报价,请点击立即获取报价或者通过电子邮件sales@crene.cn把您需要的数量信息提交给我们我们会在第一时间回复您,谢谢!
产品信息
产品名称:吡咯替尼二马来酸盐 Pyrotinib Maleate 纯度:98% min
CAS NO:1397922-61-0 溶解度:DMSO : 100 mg/mL (122.66 mM)
分子式:C40H39ClN6O11 包装:可按客户要求包装
分子量:815.224 贮存:-20 ℃
质量控制
备注说明

Pyrotinib maleate is a salt of Pyrotinib. Pyrotinib also known as SHR-1258, is an orally bioavailable, dual kinase inhibitor of the epidermal growth factor receptor (EGFR or HER-1) and the human epidermal growth factor receptor 2 (ErbB2 or HER-2), with potential antineoplastic activity. Upon oral administration, pyrotinib binds to and inhibits both EGFR and HER2, which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumor cells. EGFR and HER2 are receptor tyrosine kinases that are upregulated in various tumor cell types and play major roles in tumor cell proliferation and tumor vascularization.

参考文献
[1] Xin Li, et al. Eur J Pharm Sci. 2017 Dec 15;110:51-61.

版权所有 Copyright(C) 2018-2024 台州市科瑞生物技术有限公司

技术支持:kerui  浙ICP备09021343号-1
公司所列产品中涉及到专利,只供研发使用,不做销售;管制产品将严格遵守中国法律和购买客户国法律的规定销售,所有产品都不适用于人用 如被销售到构成专利侵权的国家,则相应的一切风险将由买方承担。