A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
中文别名:
酪氨酸磷酸化抑制剂AG490N; -苄基-2-(3,4-二羟基亚苄基)-2-氰基乙酰胺; 酪氨酸磷酸化抑制剂 B42; A-氰基-(3,4-二羟基)-N-苄基肉桂胺
物化属性:
外观与形状:黄色固体
密度:1.337
熔点:215ºC
沸点:615.2°Cat760mmHg
闪光点:325.9°C
颜色:yellow
PSA:93.35000
LOGP:2.71208