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YS-49 是 PI3K/Akt (RhoA 的下游靶标) 的激活剂,可减少 3-甲基胆碱处理的细胞中 RhoA/PTEN 的激活。YS-49 能通过诱导血红素加氧酶 (HO-1) 来抑制血管紧张素 II (Ang II) 刺激 VSMC 细胞的增殖。YS-49 是异喹啉化合物生物碱,因能激活心脏 β-adrenoceptors 而具有强烈的正性肌力作用。
中文名称:
1,2,3,4-四氢-1-(1-萘基甲基)-6,7-异喹啉二醇氢溴酸盐
[1]. Lee YS, Kim CH, Yun-Choi HS,et al. Cardiovascular effect of a naphthylmethyl substituted tetrahydroisoquinoline, YS 49, in rat and rabbit. Life Sci. 1994;55(21):PL415-20.
[2]. Kang YJ, Koo EB, Lee YS,et al. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br J Pharmacol. 1999;128(2):357-64.
[3]. Yun-Choi HS, Pyo MK, Park KM, et al. Antithrombotic effects of YS-49 and YS-51--1-naphthylmethyl analogs of higenamine . Thromb Res. 2001;104(4):249-55.
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